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Xanax is an anti-anxiety drug in the benzodiazepine family, the same family that includes diazepam (Valium), clonazepam (Klonopin), lorazepam (Ativan), flurazepam (Dalmane), and others. Xanax and other benzodiazepines act by enhancing the effects of gamma-aminobutyric acid (GABA) in the brain. GABA is a neurotransmitter (a chemical that nerve cells use to communicate with each other) that limits the activity of the brain. It is firmly believed that excessive activity in the brain may cause anxiety or other psychiatric disorders. Xanax is used for the treatment of anxiety disorders and panic attacks. Anxiety disorders are characterized by unrealistic worry and apprehension and worry, causing symptoms of restlessness, aches, trembling, shortness of breath, smothering sensation, palpitations, sweating, cold clammy hands, lightheadedness, flushing, exaggerated startle responses, problems concentrating, and insomnia. Panic attacks occur either unexpectedly or in certain situations (for example, driving), and can require higher dosages of Xanax.
Xanax may be taken with or without food and the starting dose for treating anxiety is 0.25-0.5 mg 3 times daily using immediate release tablets. The dosage of the drug may be increased every 3-4 days to a maximum dose of 4 mg daily. The initial dose for treating panic attacks is 0.5 mg 3 times daily. The effective dosage for preventing panic attacks may be as high as 6 mg daily.
Ketoconazole (Nizoral), itraconazole (Sporanox), nefazodone (Serzone), cimetidine (Tagamet), and fluvoxamine (Luvox) elevate the blood concentration of alprazolam and therefore may increase the side effects of Xanax.
Xanax interacts with alcohol and medications (for example, alcohol, barbiturates, and narcotics) by exaggerating their slowing of activity in the brain and sedation.
Xanax, such as alprazolam, can cause fetal abnormalities and should not be given with pregnant patient or nursing mothers. NURSING MOTHERS: Xanax is excreted in breast milk and can affect nursing infants. Therefore, it should not be used by women who are nursing an infant.